Photography by Lar
Photography by Lar
LONDON British scientists have identified a gene responsible for regulating chronic pain, called HCN2, and say their discovery should help drug researchers in their search for more effective, targeted pain-killing medicines.
Scientists from Cambridge University said that if drugs could be designed to block the protein produced by the gene, they could treat a type of pain known as neuropathic pain, which is linked to nerve damage and often very difficult to control with currently available drugs.
"Individuals suffering from neuropathic pain often have little or no respite because of the lack of effective medications," said Peter McNaughton of Cambridge's pharmacology department, who led the study.
"Our research lays the groundwork for the development of new drugs to treat chronic pain by blocking HCN2."
Pain is an enormous health burden worldwide, estimated to cost more than 200 billion euros ($281 billion) a year in Europe and around $150 billion a year in the United States.
Studies show that around 22 percent of people with chronic pain become depressed and 25 percent go on to lose their jobs. A 2002/03 survey by a group called Pain in Europe estimated that as many as one in five Europeans suffers chronic pain.
Scientists have known about the HCN2 gene, which is found in pain-sensitive nerve endings, for several years, but had not yet fully understood its role in regulating pain.
Because a related gene called HCN4 plays a critical role in controlling electrical activity in the heart, McNaughton's team suspected that HCN2 might have a similar function and regulate electrical activity in pain-sensitive nerves.
For the study, published in the journal Science on Thursday, the researchers engineered the removal of the HCN2 gene from pain-sensitive nerves and then used electrical stimuli on these nerves in lab dishes to find out how the nerves had been changed by pain management journal the removal of HCN2.
The scientists then studied genetically modified mice in which the HCN2 gene had been deleted. By measuring the speed the mice withdrew from different types of painful stimuli, the scientists were able pain management pdf to show that deleting the HCN2 gene took away neuropathic pain.
They also found that deleting HCN2 appeared to have no effect on normal acute pain -- such as the type of pain caused by accidentally cutting yourself or biting your own tongue -- a factor they said was important since this type of pain acts as a useful warning signal to the body.
"What is exciting about the work on the HCN2 gene is that removing it -- or blocking it pharmacologically -- eliminates neuropathic pain without affecting normal acute pain," McNaughton said in a statement about this work. "This finding could be very valuable clinically because normal pain sensation is essential for avoiding accidental damage."
Neuropathic pain, which is distinguished from inflammatory pain, is seen in patients with diabetes -- a condition which affects an estimated 280 million people around the world -- and as a painful after-effect of shingles and of chemotherapy in cancer patients. It is a also common factor in lower back pain and other chronic painful conditions.
(Reporting by Kate Kelland, Editing by Sitaraman Shankar)
The Canadian government revealed on January 27th, 2009 a temporary Home Renovation Tax Credit. This renovation credit will apply to work done on houses, cottages and condominiums owned for personal use, and projects can range from finishing a basement to remodeling a kitchen, to painting, to laying new sod. This home renovation tax credit works as follows: Homeowners can get a 15% tax credit of up to $1,350 for renovations that exceed $1,000 up to a maximum of $10,000 worth of work or materials. The renovations must take place and be completed between January 27, 2009 and January 31, 2010 to be eligible for this credit.
Under this $3-billion program, you may choose to hire a contractor or to do the work yourself. However, contractors must be registered for the GST so you cannot hire friends or family members. The Canadian government estimates that over 4 million families will take advantage and benefit from this tax credit.
The Home Renovation Tax Credit was created home renovation tips to encourage Canadians to spend now to help create jobs in industries typically hurt by an economic downturn.
"These measures to support home construction and renovation will help stimulate diy home renovation on a budget our construction and building-supplies industries," Federal Finance Minister Jim Flaherty said in his speech.
The tax credit will apply to a variety of home improvements, such as renovating a kitchen, bathroom or basement, new carpet or hardwood floors, building an addition, deck, or fence, installing a new furnace, painting the inside or outside of a house, or laying new sod. Expenses such as building permits, professional services, and equipment rentals are also eligible.
The cost of purchasing furniture, appliances, electronics, or construction equipment do not house remodeling contractor apply. Routine repairs and maintenance will also not be eligible for the credit.
Remember that the Home Renovation Tax Credit can be used in conjunction with other government renovation programs. For example, if you plan on making your home more energy-efficient, you may qualify for grants of up to $5,000 under the ecoENERGY Retrofit Program. In addition to this $5,000 grant, you will still be able to claim these renovations under the Home Renovation Tax Credit. The same is true for eligible expenditures that are claimed under the Medical Expense Tax Credit.
Here are some tips if you plan on hiring a contractor to do the renovations for you. Please make sure that your contractor is licensed and ask them to show you their license. Ask for references. A good contractor will be happy to provide you with a list of references as well as pictures showing the type of work they have done in the past. Get more than one quote and get them in writing. The quotes should outline exactly what will be done and how long it will take. Just remember that the lowest quote may not be the best. This contractor may be cutting corners. Ask to see the contractor's certificate of insurance. A standard insurance would cover worker compensation and third-party liability for everyone on the job as well as damage they may cause. If the contractor does not have insurance, you may be held liable if case of an accident.
Happy 2009 renovations!
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Rami Malek to play Freddie Mercury in Bryan Singer's Queen movie Syrian rebels use children's balloon bombs to try to bring drown Russian jets in Aleppo
LOS ANGELES -- Hot off his Emmy win for Mr. Robot, Rami Malek has signed on to play Freddie Mercury in the long-gestating Queen movie Bohemian Rhapsody, which will now be directed by X-Men maestro Bryan Singer, Mashable has confirmed.
20th Century Fox and New Regency will co-finance the project, which will be produced by Graham King of GK Films, who has been developing the
Bassam Hiji, a spokesman for the Nour al-Din al-Zinki group, said rebels made the hydrogen themselves and fitted the balloons with an improvised detonator no bigger than va personal loans a pen.
Hydrogen itself is highly explosive and the balloons burst into flame when they come into contact with heat.
"We know they are basic but they are one of the improvised weapons the fighters are in order to defend against the Russian airplanes and the regime airplanes that are bombarding the civilians," Mr Hiji said.
He estimated that fighters had released around 8,000 balloons so far but could only claim one possible hit: 11 days a Russian aircraft inhaled one of the balloons into its engine and was forced to make an emergency landing, he said. There was no way to verify the claim.
It is impossible to target a fast moving aircraft with houses for sale near me a balloon so rebel fighters release hundreds of them when aircraft are flying above in the hope that just one will find its mark.
Mr Hiji repeated the long-running rebel plea to the US and to Arab countries to supply them with shoulder-fired anti-aircraft missiles, known as manpads, so they could effectively counter the bombing of Aleppo.
"We know, the Russians know, the Iranians know, the regime knows and the international community knows that the only way we can fight their planes is if we have sophisticated anti-aircraft weapons," he said.
While the US has provided rebels with light arms and anti-tank missiles, it has refused to give them manpads out of concern that the weapons will fall into the hands of al-Qaeda or the Islamic State (Isil) and eventually be used against a Western military or civilian aircraft.
Video appears to show a Syrian regime helicopter brought down by a rebel missile
Syrian rebels use children's balloon bombs to try to bring drown Russian jets in Aleppo